House’s team rushes to treat an ailing college football star in time for the patient to try out for the NFL; Foreman’s brother (Orlando Jones) makes a surprise visit to the hospital.
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Summary: The team takes on the case of Valerie, an attractive female executive experiencing random episodes of excruciating pain. House agrees to take the case based on Valerie’s looks, and while treating her, the men on the team are charmed by Valerie’s beauty and personality, with Thirteen looking beyond the superficial to try to discover a link to her illness. Meanwhile, House uncharacteristically attempts to alleviate his conscience by reaching out to a former medical school colleague he wronged.
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A drug dealer collapses during a sale, but refuses to reveal personal information to the team because it might incriminate him. Meanwhile, Foreman’s teammates conspire to play a practical joke on him, while House and Wilson both aim their sights on an attractive new neighbor, Nora.
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Wilson works on a case involving his old friend (Joshua Malina), and he makes a bet with House that the diagnosis is not the return of cancer. Meanwhile, Cuddy has questions about real estate, so she turns to Wilson.
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It’s Thanksgiving, and the team discover they have little to be thankful for in their personal lives. Meanwhile, House takes on the illness of a brilliant physicist who has rejected his intellect to work as a courier.
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While Cuddy deals with her personal relationships, House is finally reinstated and takes on the case of a porn star with eye pain.
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House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.
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A dying patient insists that he has the same disease affecting his heart that killed his father and grandfather at the age of 40. Meanwhile, House discovers that he has a hearing problem while trying to duck student rounds.

A wealthy businessman brings his teenage son to the hospital and insists on having House handle the case; Foreman and Chase prepare to present information on the Dibala case.
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House’s team struggles with an African politician who falls ill and decide if they want to help him after he’s charged for crimes against humanity in his country.