Wilson works on a case involving his old friend (Joshua Malina), and he makes a bet with House that the diagnosis is not the return of cancer. Meanwhile, Cuddy has questions about real estate, so she turns to Wilson.
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Career pressures result in Nathan and Haley making a difficult choice for their family. Meanwhile, Brooke is not pleased when Julian tells Alex a secret; Clay tries to get his career back; and Millicent finds a surprising ally in Victoria
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Thanksgiving dinner becomes uncomfortable for Serena when Lily invites Trip and his wife to attend. Meanwhile, Blair thinks her mom is keeping a secret from her; Rufus discovers Lily has been lying about Cece; and Vanessa has a fight with her mother
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Noah has a surprise run-in with visitors; Samuel makes progress on his plan; Peter goes to extremes to obtain what he wants; and Claire comes to an unexpected destination
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Darryl organizes an art show of Roxie’s work at his mansion; Joanna tries to use her power to get her life back in order; Kat doesn’t know how to move on.
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Jax and Clay keep SAMCRO focused on their impending showdown with Zobelle’s group; thanks to Gemma, Tara improves her job security at the hospital; Weston finally discovers his boss’s intentions in Charming.
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Erica joins forces with an ally to investigate a biological threat. Elsewhere Anna visits a special guest. Chad has second thoughts about the V’s after some disturbing proof from a report.
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H.R.G. hosts an untraditional Thanksgiving dinner. Elsewhere, the Petrelli family gets a surprise guest at their table. Meanwhile, Samuel continues to hold Hiro hostage, as Lydia goes in search for the truth.
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Barry Kripke embarrasses Sheldon on NPR, and the gang rallies to help him get his revenge. Wolowitz, desperate to keep his romance with Bernadette alive, gets advice from a fantasy version of Katee Sackhoff.
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Barney’s unhappy after a slap bet is bequeathed to Ted and Robin by Marshall. Lily’s long-absent father arrives for Thanksgiving.
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