Oliver tries to help a young street girl, Mia AKA Speedy, get out of her dangerous life by offering to train her, but Mia double crosses him. Lois asks Clark to help her land a job as an on-air television host, but the two are shocked when the station wants to hire them as a team.
When the hospital lab tech, Isaac, discovers he has an inoperable tumor wrapped around his spine, he turns to Derek for help; Derek challenges Richard’s authority.
As Vicki’s (Kayla Ewell) behavior becomes more dangerous, Stefan (Paul Wesley) tries to help her. Elena (Nina Dobrev) tries to convince Jeremy (Steven R. McQueen) to stay away from Vicki. Caroline (Candice Accola) gives Bonnie (Katerina Graham) a necklace she took from Damon (Ian Somerhalder) to wear with her Halloween costume, and when Damon tries to take it back, he is surprised by Bonnie’s abilities. Bonnie discusses the incident with Grams (guest star Jasmine Guy) and learns more about her family’s past. Trying to cheer Vicki up, Matt (Zach Roerig) takes her to the high school’shaunted house, but the evening soon takes a terrifying turn.
The office plans a haunted house for children in the community; Michael falls into a koi pond at an important business meeting.
Sam and Dean discover a witch is running a high-stakes poker game where the currency is life years vs. money. Bobby sees the game as a chance to get out of the wheelchair and bets 25 years, but loses. As Bobby begins to age rapidly, Dean steps in to save him but also ends up turning into an old man, leaving Sam holding the bag for their survival.
Mark, Demetri and Wedeck try to connect Janis’ attack with a separate attack made on them; Olivia confronts Mark about his flashforward; Demetri and Gough track down a clue from Mark’s flash; Dylan goes missing from the hospital
Liz (Tina Fey) and Jack (Alec Baldwin) venture down south to Kenneth’s (Jack McBrayer) hometown to discover new talent. Jenna (Jane Krakowski) tries to make friends with the writers to solidify her place at “TGS” before the new cast member is hired. Meanwhile, Tracy (Tracy Morgan) fears for his life when two celebrities die and he believes he’s the next to bite the dust. Scott Adsit, Judah Friedlander and Keith Powell also star
Sean makes an important decision without consulting anyone; a morose Annie shows up in L.A. with a troubling medical condition; Christian gives Mike (Mario Lopez) tips on how to satisfy Kimber; and a new patient recognizes Teddy.
When Josh tells Jules he’s in love with her, she knows the time has come to break things off with him. Unfortunately for Jules, she’s not the best at ending relationships without hurting people’s feelings, but thankfully she has the expertise of friends Laurie and Ellie to see her through. Meanwhile, Bobby, Grayson and Andy hit the links with money and pride on the line.
Stan and his family are spending his birthday at the Denver Aquarium where they will get to swim with the dolphins. Things turn bloody when the Japanese attack, kill all the dolphins and ruin Stan’s big day. There seems to be no end to the senseless killing. Stan takes on the cause to save the dolphins from the Japanese.